RNA Details
Disease Name
scleroderma systemic
Tissue
skin
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
SMAD7
Pathway
NA
PubMed ID
Title
MicroRNA-21 in scleroderma fibrosis and its function in TGF-beta-regulated fibrosis-related genes expression
Year
2013
Function
"Mir-21 may function in an amplifying circuit to enhance tgf-beta signaling events in ssc fibrosis, and suggesting that mir-21 may act as a potential therapeutic target."